|
KMID : 0359320080480010027
|
|
Korean Journal of Veterinary Research
2008 Volume.48 No. 1 p.27 ~ p.32
|
|
|
Development and sustained release effect of implantable formula of somatotropin
|
|
Kim Nam-Joong
|
|
|
Abstract
|
|
|
|
The present study was carried out to develop a sustained release implantable formula of bovine somatotropin (SRIF-BST) and to examine its sustained release effect. The SRIF-BST was produced by coating a solid pellet, which was comprised of BST and an excipient, made of a biodegradable polymer and poloxamer, which are capable of regulating the rate of BST release. The coated membrane of SRIFBST was observed with a field emission scanning electron microscope. The thickness of the coated membrane was approximately 1 μm, and the pore sizes of the coated membrane surface were below 10 μm. In dissolution test, the release duration of the SRIF-BST maintained for 10 days, whereas the release duration of the control BST formula maintained for 3 days. In weight gain assay and tibia test of hypophysectomized rats, the release duration of the SRIF-BST treated group was 12 days and the net weight gain was 53.16 g, also the tibia length and strength of the SRIF-BST treated group was increased 10.5% and 23.1% compared with those of the control group, respectively.
|
|
|
KEYWORD
|
|
|
hypophysectomized rat, somatotropin, sustained release implantable formula, SRIF
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|